Ekeler also suffered a hyperextended knee, but it is not viewed as significant of an issue as the hamstring injury, a source said.
Ekeler is seeking a second opinion on his hamstring and timeline for a return, Schefter reported.
Ekeler left Sunday’s game against the Tampa Bay Buccaneers on crutches and with a brace before undergoing an MRI on Monday.
Ekeler had 12 yards on two carries and one reception for 2 yards before leaving with 1:37 left in the first quarter of Los Angeles’ 38-31 loss. He leads the Chargers with 248 rushing yards and is third on the team with 144 receiving yards this season.
He signed a four-year, $24.5 million extension with the Chargers in the offseason. After a lengthy contract dispute with Melvin Gordon, Los Angeles signed Ekeler long term instead.
Gordon eventually signed with the Denver Broncos, clearing the way for Ekeler to be the Chargers’ featured back.
Without Ekeler, the Chargers’ run game suffered in Tampa. Quarterback Justin Herbert led the team in rushing with 14 yards. As a team, they ran for 46 yards on 23 carries.